Wizard with a Gun features five biomes for the player to explore, each with its own assortment of creatures, loot, and challenges to face:
- The Tower, the home base outside of the shattered reality.
- The Imperium, temperate remnants of the once glorious wizardly nation.
- The Fell, a swampland as poisonous as it is full of opportunities.
- The Frozen Wastes, far to the north, frozen and full of barbarians.
- The Barren Sea, a wrecked expanse where a sea once lay.